Vitamin D-binding protein (GC)

About Vitamin D-binding protein

Vitamin D-binding protein (GC) is a protein from Homo sapiens identified by UniProt accession P02774, 474 residues long. MolForge cross-references it against 0 known binders and 408 disease associations.

Target properties

Protein name	Vitamin D-binding protein
UniProt accession	P02774
Gene	GC
Organism	Homo sapiens
Length	474 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (408)

Diseases linked to this target (Open Targets).

vitamin D measurement · score 0.66
vitamin D-binding protein measurement · score 0.48
neutrophil count · score 0.48
lymphocyte count · score 0.48
blood protein measurement · score 0.45
leukocyte count · score 0.43
platelet count · score 0.42
monocyte count · score 0.42
platelet crit · score 0.42
vitamin D deficiency · score 0.41

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P02774-F1	alphafold	PREDICTED	92.71	—

Amino-acid sequence (474 residues)

MKRVLVLLLA VAFGHALERG RDYEKNKVCK EFSHLGKEDF TSLSLVLYSR KFPSGTFEQV SQLVKEVVSL TEACCAEGAD PDCYDTRTSA LSAKSCESNS PFPVHPGTAE CCTKEGLERK LCMAALKHQP QEFPTYVEPT NDEICEAFRK DPKEYANQFM WEYSTNYGQA PLSLLVSYTK SYLSMVGSCC TSASPTVCFL KERLQLKHLS LLTTLSNRVC SQYAAYGEKK SRLSNLIKLA QKVPTADLED VLPLAEDITN ILSKCCESAS EDCMAKELPE HTVKLCDNLS TKNSKFEDCC QEKTAMDVFV CTYFMPAAQL PELPDVELPT NKDVCDPGNT KVMDKYTFEL SRRTHLPEVF LSKVLEPTLK SLGECCDVED STTCFNAKGP LLKKELSSFI DKGQELCADY SENTFTEYKK KLAERLKAKL PDATPTELAK LVNKHSDFAS NCCSINSPPL YCDSEIDAEL KNIL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards