Vitamin D 25-hydroxylase (CYP2R1)
Homo sapiens — UniProt Q6VVX0
Data last refreshed: (UniProt release unknown)
Key facts
Vitamin D 25-hydroxylase (CYP2R1) is a protein from Homo sapiens identified by UniProt accession Q6VVX0, 501 residues long. MolForge cross-references it against 3 known binders and 154 disease associations.
- UniProt accession: Q6VVX0; gene symbol CYP2R1.
- Organism: Homo sapiens.
- Length: 501 amino acids.
- Top disease associations (Open Targets): vitamin D measurement, Hypocalcemic vitamin D-dependent rickets and vitamin D deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Vitamin D 25-hydroxylase |
|---|---|
| UniProt accession | Q6VVX0 |
| Gene | CYP2R1 |
| Organism | Homo sapiens |
| Length | 501 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (154)
Diseases linked to this target (Open Targets).
- vitamin D measurement · score 0.70
- Hypocalcemic vitamin D-dependent rickets · score 0.70
- vitamin D deficiency · score 0.38
- rickets · score 0.37
- HbA1c measurement · score 0.32
- vitamin D dietary intake measurement · score 0.28
- vitamin D-dependent rickets, type 1 · score 0.27
- ovarian cancer · score 0.25
- BMI-adjusted waist-hip ratio · score 0.24
- head and neck squamous cell carcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6VVX0-F1 | alphafold | PREDICTED | 96.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6VVX0.
Amino-acid sequence (501 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CYP2R1?
The strongest Open Targets associations for CYP2R1 are vitamin D measurement, Hypocalcemic vitamin D-dependent rickets, vitamin D deficiency, rickets and HbA1c measurement.
How long is the CYP2R1 protein?
The Homo sapiens CYP2R1 protein (UniProt Q6VVX0) is 501 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6VVX0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6VVX0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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