About Vitamin D3 receptor
Vitamin D3 receptor (VDR) is a protein
from Homo sapiens identified by UniProt accession
P11473, 427 residues long.
MolForge cross-references it against 0 known binders and
1,279 disease associations.
Target properties
| Protein name | Vitamin D3 receptor |
|---|
| UniProt accession | P11473 |
|---|
| Gene | VDR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 427 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (12)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1279)
Diseases linked to this target (Open Targets).
- Hypocalcemic vitamin D-resistant rickets · score 0.84
- osteoporosis · score 0.62
- psoriasis · score 0.62
- chronic kidney disease · score 0.62
- vitamin D deficiency · score 0.61
- secondary hyperparathyroidism · score 0.60
- COVID-19 · score 0.60
- psoriasis vulgaris · score 0.60
- Hypocalcemia · score 0.59
- postmenopausal osteoporosis · score 0.58
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11473-F1 | alphafold | PREDICTED | 83.56 | — |
Amino-acid sequence (427 residues)
MEAMAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR SMKRKALFTC PFNGDCRITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV QRKREMILKR KEEEALKDSL RPKLSEEQQR IIAILLDAHH KTYDPTYSDF CQFRPPVRVN DGGGSHPSRP NSRHTPSFSG DSSSSCSDHC ITSSDMMDSS SFSNLDLSEE DSDDPSVTLE LSQLSMLPHL ADLVSYSIQK VIGFAKMIPG FRDLTSEDQI VLLKSSAIEV IMLRSNESFT MDDMSWTCGN QDYKYRVSDV TKAGHSLELI EPLIKFQVGL KKLNLHEEEH VLLMAICIVS PDRPGVQDAA LIEAIQDRLS NTLQTYIRCR HPPPGSHLLY AKMIQKLADL RSLNEEHSKQ YRCLSFQPEC SMKLTPLVLE VFGNEIS
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