About Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3 (ST8SIA3) is a protein
from Homo sapiens identified by UniProt accession
O43173, 380 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3 |
|---|
| UniProt accession | O43173 |
|---|
| Gene | ST8SIA3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 380 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (43)
Diseases linked to this target (Open Targets).
- body height · score 0.33
- sex hormone-binding globulin measurement · score 0.08
- C-reactive protein measurement · score 0.05
- alkaline phosphatase measurement · score 0.05
- alcohol consumption measurement · score 0.05
- glioblastoma multiforme · score 0.04
- atypical teratoid rhabdoid tumor · score 0.04
- urate measurement · score 0.04
- bone density · score 0.04
- lung carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43173-F1 | alphafold | PREDICTED | 86.62 | — |
Amino-acid sequence (380 residues)
MRNCKMARVA SVLGLVMLSV ALLILSLISY VSLKKENIFT TPKYASPGAP RMYMFHAGFR SQFALKFLDP SFVPITNSLT QELQEKPSKW KFNRTAFLHQ RQEILQHVDV IKNFSLTKNS VRIGQLMHYD YSSHKYVFSI SNNFRSLLPD VSPIMNKHYN ICAVVGNSGI LTGSQCGQEI DKSDFVFRCN FAPTEAFQRD VGRKTNLTTF NPSILEKYYN NLLTIQDRNN FFLSLKKLDG AILWIPAFFF HTSATVTRTL VDFFVEHRGQ LKVQLAWPGN IMQHVNRYWK NKHLSPKRLS TGILMYTLAS AICEEIHLYG FWPFGFDPNT REDLPYHYYD KKGTKFTTKW QESHQLPAEF QLLYRMHGEG LTKLTLSHCA
Explore Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets