About Interleukin-1 receptor-associated kinase-like 2
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) is a protein
from Homo sapiens identified by UniProt accession
O43187, 625 residues long.
MolForge cross-references it against 0 known binders and
141 disease associations.
Target properties
| Protein name | Interleukin-1 receptor-associated kinase-like 2 |
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| UniProt accession | O43187 |
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| Gene | IRAK2 |
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| Organism | Homo sapiens |
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| Length | 625 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (141)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.41
- severe acute respiratory syndrome · score 0.37
- neuroinflammatory disorder · score 0.37
- eosinophil percentage of leukocytes · score 0.34
- eosinophil percentage of granulocytes · score 0.28
- sum of eosinophil and basophil counts · score 0.24
- neurodegenerative disease · score 0.24
- thyroid gland adenocarcinoma · score 0.23
- neutrophil percentage of granulocytes · score 0.23
- C-reactive protein measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43187-F1 | alphafold | PREDICTED | 67.95 | — |
Amino-acid sequence (625 residues)
MACYIYQLPS WVLDDLCRNM DALSEWDWME FASYVITDLT QLRKIKSMER VQGVSITREL LWWWGMRQAT VQQLVDLLCR LELYRAAQII LNWKPAPEIR CPIPAFPDSV KPEKPLAASV RKAEDEQEEG QPVRMATFPG PGSSPARAHQ PAFLQPPEED APHSLRSDLP TSSDSKDFST SIPKQEKLLS LAGDSLFWSE ADVVQATDDF NQNRKISQGT FADVYRGHRH GKPFVFKKLR ETACSSPGSI ERFFQAELQI CLRCCHPNVL PVLGFCAARQ FHSFIYPYMA NGSLQDRLQG QGGSDPLPWP QRVSICSGLL CAVEYLHGLE IIHSNVKSSN VLLDQNLTPK LAHPMAHLCP VNKRSKYTMM KTHLLRTSAA YLPEDFIRVG QLTKRVDIFS CGIVLAEVLT GIPAMDNNRS PVYLKDLLLS DIPSSTASLC SRKTGVENVM AKEICQKYLE KGAGRLPEDC AEALATAACL CLRRRNTSLQ EVCGSVAAVE ERLRGRETLL PWSGLSEGTG SSSNTPEETD DVDNSSLDAS SSMSVAPWAG AATPLLPTEN GEGRLRVIVG READSSSEAC VGLEPPQDVT ETSWQIEINE AKRKLMENIL LYKEEKVDSI ELFGP
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