About Leucine-rich repeat transmembrane neuronal protein 2
Leucine-rich repeat transmembrane neuronal protein 2 (LRRTM2) is a protein
from Homo sapiens identified by UniProt accession
O43300, 516 residues long.
MolForge cross-references it against 0 known binders and
48 disease associations.
Target properties
| Protein name | Leucine-rich repeat transmembrane neuronal protein 2 |
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| UniProt accession | O43300 |
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| Gene | LRRTM2 |
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| Organism | Homo sapiens |
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| Length | 516 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (48)
Diseases linked to this target (Open Targets).
- thyroid gland adenocarcinoma · score 0.18
- risk-taking behaviour · score 0.09
- bone density · score 0.06
- urate measurement · score 0.06
- Senior-Boichis syndrome · score 0.06
- hepatorenocardiac degenerative fibrosis · score 0.05
- kidney disease · score 0.05
- C-reactive protein measurement · score 0.05
- breast carcinoma · score 0.04
- squamous cell carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43300-F1 | alphafold | PREDICTED | 79.14 | — |
Amino-acid sequence (516 residues)
MGLHFKWPLG APMLAAIYAM SMVLKMLPAL GMACPPKCRC EKLLFYCDSQ GFHSVPNATD KGSLGLSLRH NHITELERDQ FASFSQLTWL HLDHNQISTV KEDAFQGLYK LKELILSSNK IFYLPNTTFT QLINLQNLDL SFNQLSSLHP ELFYGLRKLQ TLHLRSNSLR TIPVRLFWDC RSLEFLDLST NRLRSLARNG FAGLIKLREL HLEHNQLTKI NFAHFLRLSS LHTLFLQWNK ISNLTCGMEW TWGTLEKLDL TGNEIKAIDL TVFETMPNLK ILLMDNNKLN SLDSKILNSL RSLTTVGLSG NLWECSARIC ALASWLGSFQ GRWEHSILCH SPDHTQGEDI LDAVHGFQLC WNLSTTVTVM ATTYRDPTTE YTKRISSSSY HVGDKEIPTT AGIAVTTEEH FPEPDNAIFT QRVITGTMAL LFSFFFIIFI VFISRKCCPP TLRRIRQCSM VQNHRQLRSQ TRLHMSNMSD QGPYNEYEPT HEGPFIIING YGQCKCQQLP YKECEV
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