Thioredoxin-like protein 1 (TXNL1)

About Thioredoxin-like protein 1

Thioredoxin-like protein 1 (TXNL1) is a protein from Homo sapiens identified by UniProt accession O43396, 289 residues long. MolForge cross-references it against 0 known binders and 132 disease associations.

Target properties

Protein name	Thioredoxin-like protein 1
UniProt accession	O43396
Gene	TXNL1
Organism	Homo sapiens
Length	289 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (132)

Diseases linked to this target (Open Targets).

balding measurement · score 0.19
vital capacity · score 0.14
mathematical ability · score 0.13
schizophrenia · score 0.13
hypertrophic cardiomyopathy · score 0.07
chronic obstructive pulmonary disease · score 0.06
primary familial polycythemia due to EPO receptor mutation · score 0.06
bone density · score 0.05
urate measurement · score 0.05
alpha-thalassemia-myelodysplastic syndrome · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43396-F1	alphafold	PREDICTED	91.59	—

Amino-acid sequence (289 residues)

MVGVKPVGSD PDFQPELSGA GSRLAVVKFT MRGCGPCLRI APAFSSMSNK YPQAVFLEVD VHQCQGTAAT NNISATPTFL FFRNKVRIDQ YQGADAVGLE EKIKQHLEND PGSNEDTDIP KGYMDLMPFI NKAGCECLNE SDEHGFDNCL RKDTTFLESD CDEQLLITVA FNQPVKLYSM KFQGPDNGQG PKYVKIFINL PRSMDFEEAE RSEPTQALEL TEDDIKEDGI VPLRYVKFQN VNSVTIFVQS NQGEEETTRI SYFTFIGTPV QATNMNDFKR VVGKKGESH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards