About Protein CBFA2T2
Protein CBFA2T2 (CBFA2T2) is a protein
from Homo sapiens identified by UniProt accession
O43439, 604 residues long.
MolForge cross-references it against 0 known binders and
217 disease associations.
Target properties
| Protein name | Protein CBFA2T2 |
|---|
| UniProt accession | O43439 |
|---|
| Gene | CBFA2T2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 604 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (217)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.19
- BMI-adjusted hip circumference · score 0.19
- fat body mass · score 0.18
- whole body water mass · score 0.14
- appendicular lean mass · score 0.13
- forced expiratory volume · score 0.11
- mean corpuscular volume · score 0.11
- triglyceride measurement · score 0.10
- azoospermia · score 0.08
- heel bone mineral density · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43439-F1 | alphafold | PREDICTED | 63.69 | — |
Amino-acid sequence (604 residues)
MAKESGISLK EIQVLARQWK VGPEKRVPAM PGSPVEVKIQ SRSSPPTMPP LPPINPGGPR PVSFTPTALS NGINHSPPTL NGAPSPPQRF SNGPASSTSS ALTNQQLPAT CGARQLSKLK RFLTTLQQFG NDISPEIGEK VRTLVLALVN STVTIEEFHC KLQEATNFPL RPFVIPFLKA NLPLLQRELL HCARAAKQTP SQYLAQHEHL LLNTSIASPA DSSELLMEVH GNGKRPSPER REENSFDRDT IAPEPPAKRV CTISPAPRHS PALTVPLMNP GGQFHPTPPP LQHYTLEDIA TSHLYREPNK MLEHREVRDR HHSLGLNGGY QDELVDHRLT EREWADEWKH LDHALNCIME MVEKTRRSMA VLRRCQESDR EELNYWKRRY NENTELRKTG TELVSRQHSP GSADSLSNDS QREFNSRPGT GYVPVEFWKK TEEAVNKVKI QAMSEVQKAV AEAEQKAFEV IATERARMEQ TIADVKRQAA EDAFLVINEQ EESTENCWNC GRKASETCSG CNIARYCGSF CQHKDWERHH RLCGQNLHGQ SPHGQGRPLL PVGRGSSARS ADCSVPSPAL DKTSATTSRS STPASVTAID TNGL
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