About Membrane-bound transcription factor site-2 protease
Membrane-bound transcription factor site-2 protease (MBTPS2) is a protein
from Homo sapiens identified by UniProt accession
O43462, 519 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | Membrane-bound transcription factor site-2 protease |
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| UniProt accession | O43462 |
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| Gene | MBTPS2 |
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| Organism | Homo sapiens |
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| Length | 519 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (80)
Diseases linked to this target (Open Targets).
- IFAP syndrome 1, with or without BRESHECK syndrome · score 0.76
- keratosis follicularis spinulosa decalvans · score 0.66
- osteogenesis imperfecta · score 0.51
- neurodegenerative disease · score 0.50
- IFAP syndrome · score 0.46
- cicatricial alopecia · score 0.46
- BRESEK syndrome · score 0.38
- Olmsted syndrome 1 · score 0.38
- osteogenesis imperfecta type 3 · score 0.37
- Olmsted syndrome · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43462-F1 | alphafold | PREDICTED | 87.05 | — |
Amino-acid sequence (519 residues)
MIPVSLVVVV VGGWTVVYLT DLVLKSSVYF KHSYEDWLEN NGLSISPFHI RWQTAVFNRA FYSWGRRKAR MLYQWFNFGM VFGVIAMFSS FFLLGKTLMQ TLAQMMADSP SSYSSSSSSS SSSSSSSSSS SSSSSSLHNE QVLQVVVPGI NLPVNQLTYF FTAVLISGVV HEIGHGIAAI REQVRFNGFG IFLFIIYPGA FVDLFTTHLQ LISPVQQLRI FCAGIWHNFV LALLGILALV LLPVILLPFY YTGVGVLITE VAEDSPAIGP RGLFVGDLVT HLQDCPVTNV QDWNECLDTI AYEPQIGYCI SASTLQQLSF PVRAYKRLDG STECCNNHSL TDVCFSYRNN FNKRLHTCLP ARKAVEATQV CRTNKDCKKS SSSSFCIIPS LETHTRLIKV KHPPQIDMLY VGHPLHLHYT VSITSFIPRF NFLSIDLPVV VETFVKYLIS LSGALAIVNA VPCFALDGQW ILNSFLDATL TSVIGDNDVK DLIGFFILLG GSVLLAANVT LGLWMVTAR
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