Histone-lysine N-methyltransferase SUV39H1 (SUV39H1)

About Histone-lysine N-methyltransferase SUV39H1

Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) is a protein from Homo sapiens identified by UniProt accession O43463, 412 residues long. MolForge cross-references it against 0 known binders and 144 disease associations.

Target properties

Protein name	Histone-lysine N-methyltransferase SUV39H1
UniProt accession	O43463
Gene	SUV39H1
Organism	Homo sapiens
Length	412 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (144)

Diseases linked to this target (Open Targets).

endometrial cancer · score 0.13
ependymoma · score 0.11
neoplasm · score 0.11
acute myeloid leukemia · score 0.10
breast cancer · score 0.09
hepatocellular carcinoma · score 0.09
non-small cell lung carcinoma · score 0.08
chronic obstructive pulmonary disease · score 0.08
Systemic lupus erythematosus · score 0.08
nonpapillary renal cell carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43463-F1	alphafold	PREDICTED	88.49	—

Amino-acid sequence (412 residues)

MAENLKGCSV CCKSSWNQLQ DLCRLAKLSC PALGISKRNL YDFEVEYLCD YKKIREQEYY LVKWRGYPDS ESTWEPRQNL KCVRILKQFH KDLERELLRR HHRSKTPRHL DPSLANYLVQ KAKQRRALRR WEQELNAKRS HLGRITVENE VDLDGPPRAF VYINEYRVGE GITLNQVAVG CECQDCLWAP TGGCCPGASL HKFAYNDQGQ VRLRAGLPIY ECNSRCRCGY DCPNRVVQKG IRYDLCIFRT DDGRGWGVRT LEKIRKNSFV MEYVGEIITS EEAERRGQIY DRQGATYLFD LDYVEDVYTV DAAYYGNISH FVNHSCDPNL QVYNVFIDNL DERLPRIAFF ATRTIRAGEE LTFDYNMQVD PVDMESTRMD SNFGLAGLPG SPKKRVRIEC KCGTESCRKY LF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards