About Trans-Golgi network integral membrane protein 2
Trans-Golgi network integral membrane protein 2 (TGOLN2) is a protein
from Homo sapiens identified by UniProt accession
O43493, 437 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Trans-Golgi network integral membrane protein 2 |
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| UniProt accession | O43493 |
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| Gene | TGOLN2 |
|---|
| Organism | Homo sapiens |
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| Length | 437 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (53)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.31
- leukocyte count · score 0.31
- high density lipoprotein cholesterol measurement · score 0.30
- apolipoprotein A 1 measurement · score 0.26
- hemoglobin measurement · score 0.24
- hematocrit · score 0.24
- neutrophil percentage of leukocytes · score 0.23
- myeloid white cell count · score 0.22
- lymphocyte percentage of leukocytes · score 0.20
- brain measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43493-F1 | alphafold | PREDICTED | 49.21 | — |
Amino-acid sequence (437 residues)
MRFVVALVLL NVAAAGAVPL LATESVKQEE AGVRPSAGNV STHPSLSQRP GGSTKSHPEP QTPKDSPSKS SAEAQTPEDT PNKSGAEAKT QKDSSNKSGA EAKTQKGSTS KSGSEAQTTK DSTSKSHPEL QTPKDSTGKS GAEAQTPEDS PNRSGAEAKT QKDSPSKSGS EAQTTKDVPN KSGADGQTPK DGSSKSGAED QTPKDVPNKS GAEKQTPKDG SNKSGAEEQG PIDGPSKSGA EEQTSKDSPN KVVPEQPSRK DHSKPISNPS DNKELPKADT NQLADKGKLS PHAFKTESGE ETDLISPPQE EVKSSEPTED VEPKEAEDDD TGPEEGSPPK EEKEKMSGSA SSENREGTLS DSTGSEKDDL YPNGSGNGSA ESSHFFAYLV TAAILVAVLY IAHHNKRKII AFVLEGKRSK VTRRPKASDY QRLDQKS
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