About Tumor necrosis factor ligand superfamily member 12
Tumor necrosis factor ligand superfamily member 12 (TNFSF12) is a protein
from Homo sapiens identified by UniProt accession
O43508, 249 residues long.
MolForge cross-references it against 0 known binders and
438 disease associations.
Target properties
| Protein name | Tumor necrosis factor ligand superfamily member 12 |
|---|
| UniProt accession | O43508 |
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| Gene | TNFSF12 |
|---|
| Organism | Homo sapiens |
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| Length | 249 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (438)
Diseases linked to this target (Open Targets).
- common variable immunodeficiency · score 0.43
- sex hormone-binding globulin measurement · score 0.29
- neurodegenerative disease · score 0.27
- high density lipoprotein cholesterol measurement · score 0.26
- blood protein measurement · score 0.26
- body fat percentage · score 0.25
- smoking status measurement · score 0.25
- aspartate aminotransferase measurement · score 0.24
- systolic blood pressure · score 0.23
- diastolic blood pressure · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43508-F1 | alphafold | PREDICTED | 77.86 | — |
Amino-acid sequence (249 residues)
MAARRSQRRR GRRGEPGTAL LVPLALGLGL ALACLGLLLA VVSLGSRASL SAQEPAQEEL VAEEDQDPSE LNPQTEESQD PAPFLNRLVR PRRSAPKGRK TRARRAIAAH YEVHPRPGQD GAQAGVDGTV SGWEEARINS SSPLRYNRQI GEFIVTRAGL YYLYCQVHFD EGKAVYLKLD LLVDGVLALR CLEEFSATAA SSLGPQLRLC QVSGLLALRP GSSLRIRTLP WAHLKAAPFL TYFGLFQVH
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