About Protein sprouty homolog 2
Protein sprouty homolog 2 (SPRY2) is a protein
from Homo sapiens identified by UniProt accession
O43597, 315 residues long.
MolForge cross-references it against 0 known binders and
501 disease associations.
Target properties
| Protein name | Protein sprouty homolog 2 |
|---|
| UniProt accession | O43597 |
|---|
| Gene | SPRY2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 315 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (501)
Diseases linked to this target (Open Targets).
- IGA glomerulonephritis · score 0.52
- body fat percentage · score 0.39
- risk-taking behaviour · score 0.37
- diabetes mellitus · score 0.36
- aspartate aminotransferase measurement · score 0.35
- type 2 diabetes mellitus · score 0.34
- body height · score 0.32
- FEV/FVC ratio · score 0.30
- platelet count · score 0.29
- cortical surface area measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43597-F1 | alphafold | PREDICTED | 62.44 | — |
Amino-acid sequence (315 residues)
MEARAQSGNG SQPLLQTPRD GGRQRGEPDP RDALTQQVHV LSLDQIRAIR NTNEYTEGPT VVPRPGLKPA PRPSTQHKHE RLHGLPEHRQ PPRLQHSQVH SSARAPLSRS ISTVSSGSRS STRTSTSSSS SEQRLLGSSF SSGPVADGII RVQPKSELKP GELKPLSKED LGLHAYRCED CGKCKCKECT YPRPLPSDWI CDKQCLCSAQ NVIDYGTCVC CVKGLFYHCS NDDEDNCADN PCSCSQSHCC TRWSAMGVMS LFLPCLWCYL PAKGCLKLCQ GCYDRVNRPG CRCKNSNTVC CKVPTVPPRN FEKPT
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