T-cell leukemia homeobox protein 3 (TLX3)

About T-cell leukemia homeobox protein 3

T-cell leukemia homeobox protein 3 (TLX3) is a protein from Homo sapiens identified by UniProt accession O43711, 291 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.

Target properties

Protein name	T-cell leukemia homeobox protein 3
UniProt accession	O43711
Gene	TLX3
Organism	Homo sapiens
Length	291 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (110)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.40
gastric carcinoma · score 0.37
colorectal adenocarcinoma · score 0.37
hepatocellular carcinoma · score 0.30
T-cell acute lymphoblastic leukemia · score 0.28
urinary bladder carcinoma · score 0.28
lung adenocarcinoma · score 0.28
acute myeloid leukemia · score 0.28
gastric intestinal type adenocarcinoma · score 0.28
cutaneous melanoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43711-F1	alphafold	PREDICTED	66.84	—

Amino-acid sequence (291 residues)

MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG RPGATYPSLP ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV PPPLPSALPA MPSVPTVSSL GGLNFPWMES SRRFVKDRFT AAAALTPFTV TRRIGHPYQN RTPPKRKKPR TSFSRVQICE LEKRFHRQKY LASAERAALA KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM LQLQHDAFQK SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards