About Integral membrane protein 2A
Integral membrane protein 2A (ITM2A) is a protein
from Homo sapiens identified by UniProt accession
O43736, 263 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | Integral membrane protein 2A |
|---|
| UniProt accession | O43736 |
|---|
| Gene | ITM2A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 263 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (70)
Diseases linked to this target (Open Targets).
- breast cancer · score 0.09
- 3-hydroxy-1-methylpropylmercapturic acid measurement · score 0.08
- Varicose veins · score 0.08
- neoplasm · score 0.06
- triple-negative breast cancer · score 0.04
- adolescent idiopathic scoliosis · score 0.03
- body height · score 0.03
- chronic lymphocytic leukemia · score 0.03
- Graves disease · score 0.03
- chronic myelogenous leukemia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43736-F1 | alphafold | PREDICTED | 80.45 | — |
Amino-acid sequence (263 residues)
MVKIAFNTPT AVQKEEARQD VEALLSRTVR TQILTGKELR VATQEKEGSS GRCMLTLLGL SFILAGLIVG GACIYKYFMP KSTIYRGEMC FFDSEDPANS LRGGEPNFLP VTEEADIRED DNIAIIDVPV PSFSDSDPAA IIHDFEKGMT AYLDLLLGNC YLMPLNTSIV MPPKNLVELF GKLASGRYLP QTYVVREDLV AVEEIRDVSN LGIFIYQLCN NRKSFRLRRR DLLLGFNKRA IDKCWKIRHF PNEFIVETKI CQE
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