About Syntaxin-6
Syntaxin-6 (STX6) is a protein
from Homo sapiens identified by UniProt accession
O43752, 255 residues long.
MolForge cross-references it against 0 known binders and
85 disease associations.
Target properties
| Protein name | Syntaxin-6 |
|---|
| UniProt accession | O43752 |
|---|
| Gene | STX6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 255 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (85)
Diseases linked to this target (Open Targets).
- brain volume measurement · score 0.30
- age at menopause · score 0.28
- progressive supranuclear palsy · score 0.27
- neuroimaging measurement · score 0.22
- thalamus volume · score 0.22
- white matter microstructure measurement · score 0.22
- cortical thickness · score 0.21
- sporadic Creutzfeld Jacob disease · score 0.21
- total blood protein measurement · score 0.18
- insomnia · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43752-F1 | alphafold | PREDICTED | 81.75 | — |
Amino-acid sequence (255 residues)
MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQDPSTATR EEIDWTTNEL RNNLRSIEWD LEDLDETISI VEANPRKFNL DATELSIRKA FITSTRQVVR DMKDQMSTSS VQALAERKNR QALLGDSGSQ NWSTGTTDKY GRLDRELQRA NSHFIEEQQA QQQLIVEQQD EQLELVSGSI GVLKNMSQRI GGELEEQAVM LEDFSHELES TQSRLDNVMK KLAKVSHMTS DRRQWCAIAI LFAVLLVVLI LFLVL
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