About Synaptogyrin-1
Synaptogyrin-1 (SYNGR1) is a protein
from Homo sapiens identified by UniProt accession
O43759, 233 residues long.
MolForge cross-references it against 0 known binders and
98 disease associations.
Target properties
| Protein name | Synaptogyrin-1 |
|---|
| UniProt accession | O43759 |
|---|
| Gene | SYNGR1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 233 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (98)
Diseases linked to this target (Open Targets).
- rheumatoid arthritis · score 0.41
- primary biliary cirrhosis · score 0.36
- serum IgG glycosylation measurement · score 0.33
- total blood protein measurement · score 0.32
- hair color · score 0.30
- Thyroid preparation use measurement · score 0.25
- blood protein measurement · score 0.21
- systemic lupus erythematosus · score 0.19
- Crohn's disease · score 0.17
- body weight · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43759-F1 | alphafold | PREDICTED | 79.41 | — |
Amino-acid sequence (233 residues)
MEGGAYGAGK AGGAFDPYTL VRQPHTILRV VSWLFSIVVF GSIVNEGYLN SASEGEEFCI YNRNPNACSY GVAVGVLAFL TCLLYLALDV YFPQISSVKD RKKAVLSDIG VSAFWAFLWF VGFCYLANQW QVSKPKDNPL NEGTDAARAA IAFSFFSIFT WAGQAVLAFQ RYQIGADSAL FSQDYMDPSQ DSSMPYAPYV EPTGPDPAGM GGTYQQPANT FDTEPQGYQS QGY
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