T-cell leukemia homeobox protein 2 (TLX2)

About T-cell leukemia homeobox protein 2

T-cell leukemia homeobox protein 2 (TLX2) is a protein from Homo sapiens identified by UniProt accession O43763, 284 residues long. MolForge cross-references it against 0 known binders and 203 disease associations.

Target properties

Protein name	T-cell leukemia homeobox protein 2
UniProt accession	O43763
Gene	TLX2
Organism	Homo sapiens
Length	284 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (203)

Diseases linked to this target (Open Targets).

neoplasm · score 0.08
Hirschsprung disease · score 0.07
cancer · score 0.07
platelet crit · score 0.07
lactose intolerance adult type · score 0.07
atresia of small intestine · score 0.07
microvillus inclusion disease · score 0.07
chronic diarrhea due to glucoamylase deficiency · score 0.07
inflammatory bowel disease 30 · score 0.07
bile acid malabsorption, primary, 1 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43763-F1	alphafold	PREDICTED	66.56	—

Amino-acid sequence (284 residues)

MEPGMLGPHN LPHHEPISFG IDQILSGPET PGGGLGLGRG GQGHGENGAF SGGYHGASGY GPAGSLAPLP GSSGVGPGGV IRVPAHRPLP VPPPAGGAPA VPGPSGLGGA GGLAGLTFPW MDSGRRFAKD RLTAALSPFS GTRRIGHPYQ NRTPPKRKKP RTSFSRSQVL ELERRFLRQK YLASAERAAL AKALRMTDAQ VKTWFQNRRT KWRRQTAEER EAERHRAGRL LLHLQQDALP RPLRPPLPPD PLCLHNSSLF ALQNLQPWAE DNKVASVSGL ASVV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards