Speckle-type POZ protein (SPOP)

About Speckle-type POZ protein

Speckle-type POZ protein (SPOP) is a protein from Homo sapiens identified by UniProt accession O43791, 374 residues long. MolForge cross-references it against 0 known binders and 234 disease associations.

Target properties

Protein name	Speckle-type POZ protein
UniProt accession	O43791
Gene	SPOP
Organism	Homo sapiens
Length	374 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (234)

Diseases linked to this target (Open Targets).

prostate adenocarcinoma · score 0.72
neurodevelopmental disorder with microcephaly and dysmorphic facies · score 0.63
neurodevelopmental disorder with relative macrocephaly and with or without cardiac or endocrine anomalies · score 0.53
neurodegenerative disease · score 0.46
prostate carcinoma · score 0.42
Endometrial Clear Cell Adenocarcinoma · score 0.37
Endometrial Endometrioid Adenocarcinoma · score 0.37
Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
bile duct carcinoma · score 0.37
nodular melanoma · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43791-F1	alphafold	PREDICTED	90.14	—

Amino-acid sequence (374 residues)

MSRVPSPPPP AEMSSGPVAE SWCYTQIKVV KFSYMWTINN FSFCREEMGE VIKSSTFSSG ANDKLKWCLR VNPKGLDEES KDYLSLYLLL VSCPKSEVRA KFKFSILNAK GEETKAMESQ RAYRFVQGKD WGFKKFIRRD FLLDEANGLL PDDKLTLFCE VSVVQDSVNI SGQNTMNMVK VPECRLADEL GGLWENSRFT DCCLCVAGQE FQAHKAILAA RSPVFSAMFE HEMEESKKNR VEINDVEPEV FKEMMCFIYT GKAPNLDKMA DDLLAAADKY ALERLKVMCE DALCSNLSVE NAAEILILAD LHSADQLKTQ AVDFINYHAS DVLETSGWKS MVVSHPHLVA EAYRSLASAQ CPFLGPPRKR LKQS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards