Origin recognition complex subunit 5 (ORC5)

About Origin recognition complex subunit 5

Origin recognition complex subunit 5 (ORC5) is a protein from Homo sapiens identified by UniProt accession O43913, 435 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.

Target properties

Protein name	Origin recognition complex subunit 5
UniProt accession	O43913
Gene	ORC5
Organism	Homo sapiens
Length	435 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (37)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
alcohol consumption measurement · score 0.34
brain volume measurement · score 0.29
cortical surface area measurement · score 0.29
cortical thickness · score 0.27
glioblastoma multiforme · score 0.26
brain measurement · score 0.23
lung adenocarcinoma · score 0.23
alcohol use disorder measurement · score 0.23
bitter alcoholic beverage consumption measurement · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43913-F1	alphafold	PREDICTED	82.18	—

Amino-acid sequence (435 residues)

MPHLENVVLC RESQVSILQS LFGERHHFSF PSIFIYGHTA SGKTYVTQTL LKTLELPHVF VNCVECFTLR LLLEQILNKL NHLSSSEDGC STEITCETFN DFVRLFKQVT TAENLKDQTV YIVLDKAEYL RDMEANLLPG FLRLQELADR NVTVLFLSEI VWEKFRPNTG CFEPFVLYFP DYSIGNLQKI LSHDHPPEYS ADFYAAYINI LLGVFYTVCR DLKELRHLAV LNFPKYCEPV VKGEASERDT RKLWRNIEPH LKKAMQTVYL REISSSQWEK LQKDDTDPGQ LKGLSAHTHV ELPYYSKFIL IAAYLASYNP ARTDKRFFLK HHGKIKKTNF LKKHEKTSNH LLGPKPFPLD RLLAILYSIV DSRVAPTANI FSQITSLVTL QLLTLVGHDD QLDGPKYKCT VSLDFIRAIA RTVNFDIIKY LYDFL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards