TYRO protein tyrosine kinase-binding protein (TYROBP)

About TYRO protein tyrosine kinase-binding protein

TYRO protein tyrosine kinase-binding protein (TYROBP) is a protein from Homo sapiens identified by UniProt accession O43914, 113 residues long. MolForge cross-references it against 0 known binders and 381 disease associations.

Target properties

Protein name	TYRO protein tyrosine kinase-binding protein
UniProt accession	O43914
Gene	TYROBP
Organism	Homo sapiens
Length	113 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (381)

Diseases linked to this target (Open Targets).

Nasu-Hakola disease · score 0.73
dementia · score 0.40
neurodegenerative disease · score 0.39
Dementia · score 0.37
genetic disorder · score 0.19
late-onset Alzheimers disease · score 0.19
Parkinson disease · score 0.12
memory impairment · score 0.12
Cerebellar atrophy · score 0.12
Cerebral cortical atrophy · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43914-F1	alphafold	PREDICTED	64.63	—

Amino-acid sequence (113 residues)

MGGLEPCSRL LLLPLLLAVS GLRPVQAQAQ SDCSCSTVSP GVLAGIVMGD LVLTVLIALA VYFLGRLVPR GRGAAEAATR KQRITETESP YQELQGQRSD VYSDLNTQRP YYK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards