About Ephrin-A2
Ephrin-A2 (EFNA2) is a protein
from Homo sapiens identified by UniProt accession
O43921, 213 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Ephrin-A2 |
|---|
| UniProt accession | O43921 |
|---|
| Gene | EFNA2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 213 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (63)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.19
- cutaneous melanoma · score 0.13
- gastric adenocarcinoma · score 0.11
- attention deficit hyperactivity disorder · score 0.09
- attention deficit-hyperactivity disorder 8 · score 0.07
- schizophrenia 15 · score 0.07
- Tourette syndrome · score 0.06
- Phelan-McDermid syndrome · score 0.05
- autism · score 0.05
- X-linked non-syndromic intellectual disability · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43921-F1 | alphafold | PREDICTED | 79.88 | — |
Amino-acid sequence (213 residues)
MAPAQRPLLP LLLLLLPLPP PPFARAEDAA RANSDRYAVY WNRSNPRFHA GAGDDGGGYT VEVSINDYLD IYCPHYGAPL PPAERMEHYV LYMVNGEGHA SCDHRQRGFK RWECNRPAAP GGPLKFSEKF QLFTPFSLGF EFRPGHEYYY ISATPPNAVD RPCLRLKVYV RPTNETLYEA PEPIFTSNNS CSSPGGCRLF LSTIPVLWTL LGS
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