Origin recognition complex subunit 4 (ORC4)

About Origin recognition complex subunit 4

Origin recognition complex subunit 4 (ORC4) is a protein from Homo sapiens identified by UniProt accession O43929, 436 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.

Target properties

Protein name	Origin recognition complex subunit 4
UniProt accession	O43929
Gene	ORC4
Organism	Homo sapiens
Length	436 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (76)

Diseases linked to this target (Open Targets).

Ear-patella-short stature syndrome · score 0.78
microcephalic primordial dwarfism · score 0.37
diastolic blood pressure · score 0.34
urate measurement · score 0.31
monocyte count · score 0.30
glomerular filtration rate · score 0.28
sex hormone-binding globulin measurement · score 0.28
basophil count · score 0.28
body height · score 0.26
basophil percentage of leukocytes · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O43929-F1	alphafold	PREDICTED	85.89	—

Amino-acid sequence (436 residues)

MSSRKSKSNS LIHTECLSQV QRILRERFCR QSPHSNLFGV QVQYKHLSEL LKRTALHGES NSVLIIGPRG SGKTMLINHA LKELMEIEEV SENVLQVHLN GLLQINDKIA LKEITRQLNL ENVVGDKVFG SFAENLSFLL EALKKGDRTS SCPVIFILDE FDLFAHHKNQ TLLYNLFDIS QSAQTPIAVI GLTCRLDILE LLEKRVKSRF SHRQIHLMNS FGFPQYVKIF KEQLSLPAEF PDKVFAEKWN ENVQYLSEDR SVQEVLQKHF NISKNLRSLH MLLMLALNRV TASHPFMTAV DLMEASQLCS MDSKANIVHG LSVLEICLII AMKHLNDIYE EEPFNFQMVY NEFQKFVQRK AHSVYNFEKP VVMKAFEHLQ QLELIKPMER TSGNSQREYQ LMKLLLDNTQ IMNALQKYPN CPTDVRQWAT SSLSWL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards