About NUAK family SNF1-like kinase 1
NUAK family SNF1-like kinase 1 (NUAK1) is a protein
from Homo sapiens identified by UniProt accession
O60285, 661 residues long.
MolForge cross-references it against 0 known binders and
144 disease associations.
Target properties
| Protein name | NUAK family SNF1-like kinase 1 |
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| UniProt accession | O60285 |
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| Gene | NUAK1 |
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| Organism | Homo sapiens |
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| Length | 661 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (11)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (144)
Diseases linked to this target (Open Targets).
- white matter microstructure measurement · score 0.49
- neurodegenerative disease · score 0.47
- brain volume measurement · score 0.47
- neuroimaging measurement · score 0.46
- brain measurement · score 0.43
- cortical surface area measurement · score 0.43
- cortical thickness · score 0.39
- serum gamma-glutamyl transferase measurement · score 0.34
- serum alanine aminotransferase measurement · score 0.32
- PHF-tau measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60285-F1 | alphafold | PREDICTED | 61.38 | — |
Amino-acid sequence (661 residues)
MEGAAAPVAG DRPDLGLGAP GSPREAVAGA TAALEPRKPH GVKRHHHKHN LKHRYELQET LGKGTYGKVK RATERFSGRV VAIKSIRKDK IKDEQDMVHI RREIEIMSSL NHPHIISIYE VFENKDKIVI IMEYASKGEL YDYISERRRL SERETRHFFR QIVSAVHYCH KNGVVHRDLK LENILLDDNC NIKIADFGLS NLYQKDKFLQ TFCGSPLYAS PEIVNGRPYR GPEVDSWALG VLLYTLVYGT MPFDGFDHKN LIRQISSGEY REPTQPSDAR GLIRWMLMVN PDRRATIEDI ANHWWVNWGY KSSVCDCDAL HDSESPLLAR IIDWHHRSTG LQADTEAKMK GLAKPTTSEV MLERQRSLKK SKKENDFAQS GQDAVPESPS KLSSKRPKGI LKKRSNSEHR SHSTGFIEGV VGPALPSTFK MEQDLCRTGV LLPSSPEAEV PGKLSPKQSA TMPKKGILKK TQQRESGYYS SPERSESSEL LDSNDVMGSS IPSPSPPDPA RVTSHSLSCR RKGILKHSSK YSAGTMDPAL VSPEMPTLES LSEPGVPAEG LSRSYSRPSS VISDDSVLSS DSFDLLDLQE NRPARQRIRS CVSAENFLQI QDFEGLQNRP RPQYLKRYRN RLADSSFSLL TDMDDVTQVY KQALEICSKL N
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