About Leucine zipper putative tumor suppressor 3
Leucine zipper putative tumor suppressor 3 (LZTS3) is a protein
from Homo sapiens identified by UniProt accession
O60299, 673 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Leucine zipper putative tumor suppressor 3 |
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| UniProt accession | O60299 |
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| Gene | LZTS3 |
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| Organism | Homo sapiens |
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| Length | 673 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.21
- alkaline phosphatase measurement · score 0.09
- serum gamma-glutamyl transferase measurement · score 0.06
- self reported educational attainment · score 0.05
- leukocyte count · score 0.03
- colorectal adenocarcinoma · score 0.02
- atypical teratoid rhabdoid tumor · score 0.02
- glioblastoma multiforme · score 0.02
- wellbeing measurement · score 0.02
- risk-taking behaviour · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60299-F1 | alphafold | PREDICTED | 63.12 | — |
Amino-acid sequence (673 residues)
MAKLETLPVR ADPGRDPLLA FAPRPSELGP PDPRLAMGSV GSGVAHAQEF AMKSVGTRTG GGGSQGSFPG PRGSGSGASR ERPGRYPSED KGLANSLYLN GELRGSDHTD VCGNVVGSSG GSSSSGGSDK APPQYREPSH PPKLLATSGK LDQCSEPLVR PSAFKPVVPK NFHSMQNLCP PQTNGTPEGR QGPGGLKGGL DKSRTMTPAG GSGSGLSDSG RNSLTSLPTY SSSYSQHLAP LSASTSHINR IGTASYGSGS GGSSGGGSGY QDLGTSDSGR ASSKSGSSSS MGRPGHLGSG EGGGGGLPFA ACSPPSPSAL IQELEERLWE KEQEVAALRR SLEQSEAAVA QVLEERQKAW ERELAELRQG CSGKLQQVAR RAQRAQQGLQ LQVLRLQQDK KQLQEEAARL MRQREELEDK VAACQKEQAD FLPRIEETKW EVCQKAGEIS LLKQQLKDSQ ADVSQKLSEI VGLRSQLREG RASLREKEEQ LLSLRDSFSS KQASLELGEG ELPAACLKPA LTPVDPAEPQ DALATCESDE AKMRRQAGVA AAASLVSVDG EAEAGGESGT RALRREVGRL QAELAAERRA RERQGASFAE ERRVWLEEKE KVIEYQKQLQ LSYVEMYQRN QQLERRLRER GAAGGASTPT PQHGEEKKAW TPSRLERIES TEI
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