About Heterogeneous nuclear ribonucleoprotein Q
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) is a protein
from Homo sapiens identified by UniProt accession
O60506, 623 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Heterogeneous nuclear ribonucleoprotein Q |
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| UniProt accession | O60506 |
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| Gene | SYNCRIP |
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| Organism | Homo sapiens |
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| Length | 623 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (75)
Diseases linked to this target (Open Targets).
- Intellectual disability · score 0.45
- Global developmental delay · score 0.42
- Autism · score 0.42
- autism · score 0.42
- Generalized myoclonic-atonic seizure · score 0.42
- autism spectrum disorder · score 0.42
- complex neurodevelopmental disorder · score 0.37
- neutrophil count · score 0.33
- Red cell distribution width · score 0.29
- heel bone mineral density · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60506-F1 | alphafold | PREDICTED | 70.55 | — |
Amino-acid sequence (623 residues)
MATEHVNGNG TEEPMDTTSA VIHSENFQTL LDAGLPQKVA EKLDEIYVAG LVAHSDLDER AIEALKEFNE DGALAVLQQF KDSDLSHVQN KSAFLCGVMK TYRQREKQGT KVADSSKGPD EAKIKALLER TGYTLDVTTG QRKYGGPPPD SVYSGQQPSV GTEIFVGKIP RDLFEDELVP LFEKAGPIWD LRLMMDPLTG LNRGYAFVTF CTKEAAQEAV KLYNNHEIRS GKHIGVCISV ANNRLFVGSI PKSKTKEQIL EEFSKVTEGL TDVILYHQPD DKKKNRGFCF LEYEDHKTAA QARRRLMSGK VKVWGNVGTV EWADPIEDPD PEVMAKVKVL FVRNLANTVT EEILEKAFSQ FGKLERVKKL KDYAFIHFDE RDGAVKAMEE MNGKDLEGEN IEIVFAKPPD QKRKERKAQR QAAKNQMYDD YYYYGPPHMP PPTRGRGRGG RGGYGYPPDY YGYEDYYDYY GYDYHNYRGG YEDPYYGYED FQVGARGRGG RGARGAAPSR GRGAAPPRGR AGYSQRGGPG SARGVRGARG GAQQQRGRGV RGARGGRGGN VGGKRKADGY NQPDSKRRQT NNQNWGSQPI AQQPLQGGDH SGNYGYKSEN QEFYQDTFGQ QWK
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