Sushi repeat-containing protein SRPX2 (SRPX2)

About Sushi repeat-containing protein SRPX2

Sushi repeat-containing protein SRPX2 (SRPX2) is a protein from Homo sapiens identified by UniProt accession O60687, 465 residues long. MolForge cross-references it against 0 known binders and 164 disease associations.

Target properties

Protein name	Sushi repeat-containing protein SRPX2
UniProt accession	O60687
Gene	SRPX2
Organism	Homo sapiens
Length	465 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (164)

Diseases linked to this target (Open Targets).

Rolandic epilepsy - speech dyspraxia · score 0.57
rolandic epilepsy-speech dyspraxia syndrome · score 0.37
autism · score 0.12
papillary thyroid carcinoma · score 0.09
pachyonychia congenita · score 0.09
pulmonary fibrosis · score 0.08
oral squamous cell carcinoma · score 0.08
pancreatic neoplasm · score 0.07
melanoma · score 0.06
neoplasm · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60687-F1	alphafold	PREDICTED	86.76	—

Amino-acid sequence (465 residues)

MASQLTQRGA LFLLFFLTPA VTPTWYAGSG YYPDESYNEV YAEEVPQAPA LDYRVPRWCY TLNIQDGEAT CYSPKGGNYH SSLGTRCELS CDRGFRLIGR RSVQCLPSRR WSGTAYCRQM RCHALPFITS GTYTCTNGVL LDSRCDYSCS SGYHLEGDRS RICMEDGRWS GGEPVCVDID PPKIRCPHSR EKMAEPEKLT ARVYWDPPLV KDSADGTITR VTLRGPEPGS HFPEGEHVIR YTAYDRAYNR ASCKFIVKVQ VRRCPTLKPP QHGYLTCTSA GDNYGATCEY HCDGGYDRQG TPSRVCQSSR QWSGSPPICA PMKINVNVNS AAGLLDQFYE KQRLLIISAP DPSNRYYKMQ ISMLQQSTCG LDLRHVTIIE LVGQPPQEVG RIREQQLSAN IIEELRQFQR LTRSYFNMVL IDKQGIDRDR YMEPVTPEEI FTFIDDYLLS NQELTQRREQ RDICE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards