About Thiamine transporter 1
Thiamine transporter 1 (SLC19A2) is a protein
from Homo sapiens identified by UniProt accession
O60779, 497 residues long.
MolForge cross-references it against 0 known binders and
190 disease associations.
Target properties
| Protein name | Thiamine transporter 1 |
|---|
| UniProt accession | O60779 |
|---|
| Gene | SLC19A2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 497 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (190)
Diseases linked to this target (Open Targets).
- thiamine-responsive megaloblastic anemia syndrome · score 0.82
- Abnormality of the ear · score 0.34
- ear malformation · score 0.34
- blood coagulation disease · score 0.26
- hypertension · score 0.24
- blood protein measurement · score 0.19
- genetic disorder · score 0.19
- drug use measurement · score 0.17
- coagulation factor V measurement · score 0.17
- monogenic diabetes · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60779-F1 | alphafold | PREDICTED | 80.82 | — |
Amino-acid sequence (497 residues)
MDVPGPVSRR AAAAAATVLL RTARVRRECW FLPTALLCAY GFFASLRPSE PFLTPYLLGP DKNLTEREVF NEIYPVWTYS YLVLLFPVFL ATDYLRYKPV VLLQGLSLIV TWFMLLYAQG LLAIQFLEFF YGIATATEIA YYSYIYSVVD LGMYQKVTSY CRSATLVGFT VGSVLGQILV SVAGWSLFSL NVISLTCVSV AFAVAWFLPM PQKSLFFHHI PSTCQRVNGI KVQNGGIVTD TPASNHLPGW EDIESKIPLN MEEPPVEEPE PKPDRLLVLK VLWNDFLMCY SSRPLLCWSV WWALSTCGYF QVVNYTQGLW EKVMPSRYAA IYNGGVEAVS TLLGAVAVFA VGYIKISWST WGEMTLSLFS LLIAAAVYIM DTVGNIWVCY ASYVVFRIIY MLLITIATFQ IAANLSMERY ALVFGVNTFI ALALQTLLTL IVVDASGLGL EITTQFLIYA SYFALIAVVF LASGAVSVMK KCRKLEDPQS SSQVTTS
Explore Thiamine transporter 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets