Thiamine
ALIMENTARY TRACT AND METABOLISM
Also known as: thiamine (vit B1), thiamine HCl, thiamine hydrochloride, thiamine mononitrate, vitamin B1
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Thiamine is an ofp drug catalogued in DrugCentral. It was first approved by the FDA in 1993. DrugCentral lists 7 molecular targets, including thiT, HSP90AA1 and TPK1. Recorded indications include Cobalamin deficiency, Korsakoff's psychosis, Mineral deficiency and Mineral Deficiency Prevention.
- Approval status: ofp (first approved 1993 by the FDA).
- Molecular targets: thiT, HSP90AA1, TPK1 and SLC19A2 (7 listed in DrugCentral).
- Indications: Cobalamin deficiency, Korsakoff's psychosis, Mineral deficiency, Mineral Deficiency Prevention and Pernicious anemia and others.
- ATC code: A11DA01 (Vitamin B1, plain).
- Molecular formula: C12H17N4OS; molecular weight 265.35 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (9)
- Cobalamin deficiency
- Korsakoff's psychosis
- Mineral deficiency
- Mineral Deficiency Prevention
- Pernicious anemia
- Prevention of Vitamin B12 Deficiency
- Thiamin deficiency
- Vitamin deficiency
- Vitamin Deficiency Prevention
Off-label uses (1)
- Methylmalonic acidemia
Contraindications (32)
- Acute Thromboembolic Stroke
- Agoraphobia
- Alcoholism
- Atrophic gastritis
- Blood coagulation disorder
- Cardiovascular event risk
- Chronic heart failure
- Conduction disorder of the heart
- Coronary artery bypass graft
- Disease of liver
- Gastrectomy
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Gastrointestinal ulcer
- Hemophilia
- Hepatic failure
- Hypertensive disorder
- Hypokalemia
- Impaired renal function disorder
- Insomnia
- Kidney disease
- Leber's optic atrophy
- Myocardial infarction
- Myocardial infarction in recovery phase
- Myocardial ischemia
- Necrotizing enterocolitis in fetus OR newborn
- Obsessive-compulsive disorder
- Panic disorder
- Peptic ulcer
- Pregnancy, function
- + 2 more
Mechanism & targets
Molecular targets (7)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Thiamine transporter ThiT | thiT | unknown | Kd 9.91 |
| Heat shock protein HSP 90-alpha | HSP90AA1 | unknown | IC50 4.90 |
| Thiamin pyrophosphokinase 1 | TPK1 | unknown | — |
| Thiamine transporter 1 | SLC19A2 | unknown | — |
| Transketolase-like protein 1 | TKTL1 | unknown | — |
| Thiamine-triphosphatase | THTPA | unknown | — |
| Transketolase | TKT | unknown | — |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1993-12-29 | FDA | — | HOSPIRA |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
A11DA01 | ALIMENTARY TRACT AND METABOLISM › VITAMINS › VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN B6 AND B12 › Vitamin B1, plain |
Reported adverse-event signals
Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.
| MedDRA term | LLR |
|---|---|
| Systemic lupus erythematosus | 2612.4 |
| Pemphigus | 2605.0 |
| Glossodynia | 2263.1 |
| Hand deformity | 1940.4 |
| Arthropathy | 1867.0 |
| Alopecia | 1721.3 |
| Abdominal discomfort | 1665.9 |
| Wound | 1580.6 |
| Toxicity to various agents | 1579.1 |
| Synovitis | 1473.4 |
| Maternal exposure during pregnancy | 1471.1 |
| Completed suicide | 1394.8 |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Thiamine is on its molecule page.
| Molecular formula | C12H17N4OS |
|---|---|
| Molecular weight | 265.35 g/mol |
| CAS number | 59-43-8 |
| InChIKey | JZRWCGZRTZMZEH-UHFFFAOYSA-N |
| PubChem CID | 1130 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Thiamine used for?
DrugCentral lists the following indications for Thiamine: Cobalamin deficiency, Korsakoff's psychosis, Mineral deficiency, Mineral Deficiency Prevention, Pernicious anemia, Prevention of Vitamin B12 Deficiency, Thiamin deficiency and Vitamin deficiency and others.
How does Thiamine work?
Its molecular targets in DrugCentral include thiT, HSP90AA1, TPK1 and SLC19A2.
When was Thiamine first approved?
Thiamine was first approved by the FDA in 1993.
What is the chemical formula of Thiamine?
Thiamine has the molecular formula C12H17N4OS and a molecular weight of 265.35 g/mol.
Browse: all drugs starting with T · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 2832 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL1200941 — compound record and bioactivity
- PubChem CID 1130 — chemical identifiers
- DrugBank DB00152 — drug record
- FDA UNII X66NSO3N35 — substance identity
- DailyMed: FDA labels for Thiamine — current prescribing information (label search)
- UniProt P07900 (HSP90AA1) — target protein
- UniProt Q9H3S4 (TPK1) — target protein
- UniProt O60779 (SLC19A2) — target protein
- UniProt P51854 (TKTL1) — target protein
- UniProt Q9BU02 (THTPA) — target protein
- UniProt P29401 (TKT) — target protein
- FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
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