Thiamine pyrophosphokinase 1 (TPK1)
Homo sapiens — UniProt Q9H3S4
Data last refreshed: (UniProt release unknown)
Key facts
Thiamine pyrophosphokinase 1 (TPK1) is a protein from Homo sapiens identified by UniProt accession Q9H3S4, 243 residues long. MolForge cross-references it against 1 known binders and 116 disease associations.
- UniProt accession: Q9H3S4; gene symbol TPK1.
- Organism: Homo sapiens.
- Length: 243 amino acids.
- Top disease associations (Open Targets): childhood encephalopathy due to thiamine pyrophosphokinase deficiency, PHF-tau measurement and gut microbiome measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Thiamine pyrophosphokinase 1 |
|---|---|
| UniProt accession | Q9H3S4 |
| Gene | TPK1 |
| Organism | Homo sapiens |
| Length | 243 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (116)
Diseases linked to this target (Open Targets).
- childhood encephalopathy due to thiamine pyrophosphokinase deficiency · score 0.78
- PHF-tau measurement · score 0.36
- gut microbiome measurement · score 0.26
- diffuse plaque measurement · score 0.24
- genetic disorder · score 0.19
- Leigh syndrome · score 0.19
- protein measurement · score 0.17
- early-onset non-syndromic cataract · score 0.10
- hereditary hyperferritinemia with congenital cataracts · score 0.08
- isolated ectopia lentis · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3S4-F1 | alphafold | PREDICTED | 97.91 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3S4.
Amino-acid sequence (243 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TPK1?
The strongest Open Targets associations for TPK1 are childhood encephalopathy due to thiamine pyrophosphokinase deficiency, PHF-tau measurement, gut microbiome measurement, diffuse plaque measurement and genetic disorder.
How long is the TPK1 protein?
The Homo sapiens TPK1 protein (UniProt Q9H3S4) is 243 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3S4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3S4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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