Thiamine-triphosphatase (THTPA)

About Thiamine-triphosphatase

Thiamine-triphosphatase (THTPA) is a protein from Homo sapiens identified by UniProt accession Q9BU02, 230 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	Thiamine-triphosphatase
UniProt accession	Q9BU02
Gene	THTPA
Organism	Homo sapiens
Length	230 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (10)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.22
visual perception measurement · score 0.04
Familial exudative vitreoretinopathy · score 0.04
proliferative vitreoretinopathy · score 0.04
exudative vitreoretinopathy 2, X-linked · score 0.03
neuroblastoma · score 0.00
gestational diabetes · score 0.00
neoplasm · score 0.00
Thiamine deficiency · score 0.00
Leigh syndrome · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BU02-F1	alphafold	PREDICTED	86.57	—

Amino-acid sequence (230 residues)

MAQGLIEVER KFLPGPGTEE RLQELGGTLE YRVTFRDTYY DTPELSLMQA DHWLRRREDS GWELKCPGAA GVLGPHTEYK ELTAEPTIVA QLCKVLRADG LGAGDVAAVL GPLGLQEVAS FVTKRSAWKL VLLGADEEEP QLRVDLDTAD FGYAVGEVEA LVHEEAEVPT ALEKIHRLSS MLGVPAQETA PAKLIVYLQR FRPQDYQRLL EVNSSRERPQ ETEDPDHCLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards