About Transketolase-like protein 1
Transketolase-like protein 1 (TKTL1) is a protein
from Homo sapiens identified by UniProt accession
P51854, 596 residues long.
MolForge cross-references it against 0 known binders and
131 disease associations.
Target properties
| Protein name | Transketolase-like protein 1 |
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| UniProt accession | P51854 |
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| Gene | TKTL1 |
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| Organism | Homo sapiens |
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| Length | 596 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (131)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.11
- cancer · score 0.09
- oral squamous cell carcinoma · score 0.09
- melanoma · score 0.08
- inflammatory bowel disease · score 0.07
- calf circumference measurement · score 0.07
- Autosomal recessive early-onset inflammatory bowel disease · score 0.05
- eosinophilic esophagitis · score 0.04
- Crohn's disease · score 0.04
- ulcerative colitis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51854-F1 | alphafold | PREDICTED | 94.66 | — |
Amino-acid sequence (596 residues)
MADAEARAEF PEEARPDRGT LQVLQDMASR LRIHSIRATC STSSGHPTSC SSSSEIMSVL FFYIMRYKQS DPENPDNDRF VLAKRLSFVD VATGWLGQGL GVACGMAYTG KYFDRASYRV FCLMSDGESS EGSVWEAMAF ASYYSLDNLV AIFDVNRLGH SGALPAEHCI NIYQRRCEAF GWNTYVVDGR DVEALCQVFW QASQVKHKPT AVVAKTFKGR GTPSIEDAES WHAKPMPRER ADAIIKLIES QIQTSRNLDP QPPIEDSPEV NITDVRMTSP PDYRVGDKIA TRKACGLALA KLGYANNRVV VLDGDTRYST FSEIFNKEYP ERFIECFMAE QNMVSVALGC ASRGRTIAFA STFAAFLTRA FDHIRIGGLA ESNINIIGSH CGVSVGDDGA SQMALEDIAM FRTIPKCTIF YPTDAVSTEH AVALAANAKG MCFIRTTRPE TMVIYTPQER FEIGQAKVLR HCVSDKVTVI GAGITVYEAL AAADELSKQD IFIRVIDLFT IKPLDVATIV SSAKATEGRI ITVEDHYPQG GIGEAVCAAV SMDPDIQVHS LAVSGVPQSG KSEELLDMYG ISARHIIVAV KCMLLN
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