About Target of Myb1 membrane trafficking protein
Target of Myb1 membrane trafficking protein (TOM1) is a protein
from Homo sapiens identified by UniProt accession
O60784, 492 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Target of Myb1 membrane trafficking protein |
|---|
| UniProt accession | O60784 |
|---|
| Gene | TOM1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 492 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (55)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- Autoimmune enteropathy and endocrinopathy-susceptibility to chronic infections syndrome · score 0.37
- type 2 diabetes mellitus · score 0.23
- total cholesterol measurement · score 0.23
- BMI-adjusted waist-hip ratio · score 0.20
- body height · score 0.19
- ulcerative colitis · score 0.19
- BMI-adjusted hip circumference · score 0.18
- platelet count · score 0.17
- waist-hip ratio · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60784-F1 | alphafold | PREDICTED | 70.35 | — |
Amino-acid sequence (492 residues)
MDFLLGNPFS SPVGQRIEKA TDGSLQSEDW ALNMEICDII NETEEGPKDA LRAVKKRIVG NKNFHEVMLA LTVLETCVKN CGHRFHVLVA SQDFVESVLV RTILPKNNPP TIVHDKVLNL IQSWADAFRS SPDLTGVVTI YEDLRRKGLE FPMTDLDMLS PIHTPQRTVF NSETQSGQDS VGTDSSQQED SGQHAAPLPA PPILSGDTPI APTPEQIGKL RSELEMVSGN VRVMSEMLTE LVPTQAEPAD LELLQELNRT CRAMQQRVLE LIPQIANEQL TEELLIVNDN LNNVFLRHER FERFRTGQTT KAPSEAEPAA DLIDMGPDPA ATGNLSSQLA GMNLGSSSVR AGLQSLEASG RLEDEFDMFA LTRGSSLADQ RKEVKYEAPQ ATDGLAGALD ARQQSTGAIP VTQACLMEDI EQWLSTDVGN DAEEPKGVTS EEFDKFLEER AKAADRLPNL SSPSAEGPPG PPSGPAPRKK TQEKDDDMLF AL
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