About 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) is a protein
from Homo sapiens identified by UniProt accession
O60825, 505 residues long.
MolForge cross-references it against 0 known binders and
126 disease associations.
Target properties
| Protein name | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 |
|---|
| UniProt accession | O60825 |
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| Gene | PFKFB2 |
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| Organism | Homo sapiens |
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| Length | 505 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (126)
Diseases linked to this target (Open Targets).
- leukocyte count · score 0.28
- creatinine measurement · score 0.27
- neutrophil count · score 0.24
- diastolic blood pressure · score 0.23
- HbA1c measurement · score 0.23
- glomerular filtration rate · score 0.21
- calcium measurement · score 0.21
- neurodegenerative disease · score 0.20
- myeloid white cell count · score 0.18
- attention deficit hyperactivity disorder · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60825-F1 | alphafold | PREDICTED | 84.92 | — |
Amino-acid sequence (505 residues)
MSGASSSEQN NNSYETKTPN LRMSEKKCSW ASYMTNSPTL IVMIGLPARG KTYVSKKLTR YLNWIGVPTK VFNLGVYRRE AVKSYKSYDF FRHDNEEAMK IRKQCALVAL EDVKAYLTEE NGQIAVFDAT NTTRERRDMI LNFAEQNSFK VFFVESVCDD PDVIAANILE VKVSSPDYPE RNRENVMEDF LKRIECYKVT YRPLDPDNYD KDLSFIKVIN VGQRFLVNRV QDYIQSKIVY YLMNIHVQPR TIYLCRHGES EFNLLGKIGG DSGLSVRGKQ FAQALRKFLE EQEITDLKVW TSQLKRTIQT AESLGVPYEQ WKILNEIDAG VCEEMTYAEI EKRYPEEFAL RDQEKYLYRY PGGESYQDLV QRLEPVIMEL ERQGNVLVIS HQAVMRCLLA YFLDKGADEL PYLRCPLHTI FKLTPVAYGC KVETIKLNVE AVNTHRDKPT NNFPKNQTPV RMRRNSFTPL SSSNTIRRPR NYSVGSRPLK PLSPLRAQDM QEGAD
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