About Checkpoint protein HUS1
Checkpoint protein HUS1 (HUS1) is a protein
from Homo sapiens identified by UniProt accession
O60921, 280 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | Checkpoint protein HUS1 |
|---|
| UniProt accession | O60921 |
|---|
| Gene | HUS1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 280 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (44)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.28
- lung adenocarcinoma · score 0.28
- ovarian cancer · score 0.28
- head and neck squamous cell carcinoma · score 0.25
- clear cell renal carcinoma · score 0.10
- metabolite measurement · score 0.10
- refractive error measurement · score 0.08
- sphingomyelin measurement · score 0.06
- corneal topography · score 0.05
- Abnormality of refraction · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60921-F1 | alphafold | PREDICTED | 89.90 | — |
Amino-acid sequence (280 residues)
MKFRAKIVDG ACLNHFTRIS NMIAKLAKTC TLRISPDKLN FILCDKLANG GVSMWCELEQ ENFFNEFQME GVSAENNEIY LELTSENLSR ALKTAQNARA LKIKLTNKHF PCLTVSVELL SMSSSSRIVT HDIPIKVIPR KLWKDLQEPV VPDPDVSIYL PVLKTMKSVV EKMKNISNHL VIEANLDGEL NLKIETELVC VTTHFKDLGN PPLASESTHE DRNVEHMAEV HIDIRKLLQF LAGQQVNPTK ALCNIVNNKM VHFDLLHEDV SLQYFIPALS
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