Sodium channel regulatory subunit beta-2 (SCN2B)

About Sodium channel regulatory subunit beta-2

Sodium channel regulatory subunit beta-2 (SCN2B) is a protein from Homo sapiens identified by UniProt accession O60939, 215 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.

Target properties

Protein name	Sodium channel regulatory subunit beta-2
UniProt accession	O60939
Gene	SCN2B
Organism	Homo sapiens
Length	215 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (6)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (68)

Diseases linked to this target (Open Targets).

familial atrial fibrillation · score 0.42
Brugada syndrome · score 0.37
glioblastoma multiforme · score 0.21
Abnormality of the cardiovascular system · score 0.19
gastric adenocarcinoma · score 0.15
dilated cardiomyopathy · score 0.12
MODY · score 0.11
type 2 diabetes mellitus · score 0.08
type 1 diabetes mellitus · score 0.07
benign occipital epilepsy · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60939-F1	alphafold	PREDICTED	85.78	—

Amino-acid sequence (215 residues)

MHRDAWLPRP AFSLTGLSLF FSLVPPGRSM EVTVPATLNV LNGSDARLPC TFNSCYTVNH KQFSLNWTYQ ECNNCSEEMF LQFRMKIINL KLERFQDRVE FSGNPSKYDV SVMLRNVQPE DEGIYNCYIM NPPDRHRGHG KIHLQVLMEE PPERDSTVAV IVGASVGGFL AVVILVLMVV KCVRRKKEQK LSTDDLKTEE EGKTDGEGNP DDGAK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards