Glycosaminoglycan xylosylkinase (FAM20B)

About Glycosaminoglycan xylosylkinase

Glycosaminoglycan xylosylkinase (FAM20B) is a protein from Homo sapiens identified by UniProt accession O75063, 409 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.

Target properties

Protein name	Glycosaminoglycan xylosylkinase
UniProt accession	O75063
Gene	FAM20B
Organism	Homo sapiens
Length	409 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (89)

Diseases linked to this target (Open Targets).

body height · score 0.21
Coxa vara · score 0.07
Coxa Vara · score 0.07
Gollop-Wolfgang complex · score 0.07
arterial stiffness measurement · score 0.06
fibular aplasia-ectrodactyly syndrome · score 0.06
tibia, hypoplasia or aplasia of, with polydactyly · score 0.06
Blount disease · score 0.06
metaphyseal anadysplasia · score 0.06
tibial hemimelia · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75063-F1	alphafold	PREDICTED	93.18	—

Amino-acid sequence (409 residues)

MKLKQRVVLL AILLVIFIFT KVFLIDNLDT SAANREDQRA FHRMMTGLRV ELAPKLDHTL QSPWEIAAQW VVPREVYPEE TPELGAVMHA MATKKIIKAD VGYKGTQLKA LLILEGGQKV VFKPKRYSRD HVVEGEPYAG YDRHNAEVAA FHLDRILGFH RAPLVVGRFV NLRTEIKPVA TEQLLSTFLT VGNNTCFYGK CYYCRETEPA CADGDIMEGS VTLWLPDVWP LQKHRHPWGR TYREGKLARW EYDESYCDAV KKTSPYDSGP RLLDIIDTAV FDYLIGNADR HHYESFQDDE GASMLILLDN AKSFGNPSLD ERSILAPLYQ CCIIRVSTWN RLNYLKNGVL KSALKSAMAH DPISPVLSDP HLDAVDQRLL SVLATVKQCT DQFGMDTVLV EDRMPLSHL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards