About Transmembrane and coiled-coil domains protein 2
Transmembrane and coiled-coil domains protein 2 (TMCC2) is a protein
from Homo sapiens identified by UniProt accession
O75069, 709 residues long.
MolForge cross-references it against 0 known binders and
325 disease associations.
Target properties
| Protein name | Transmembrane and coiled-coil domains protein 2 |
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| UniProt accession | O75069 |
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| Gene | TMCC2 |
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| Organism | Homo sapiens |
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| Length | 709 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (325)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.54
- platelet count · score 0.43
- mean corpuscular hemoglobin concentration · score 0.43
- mean corpuscular volume · score 0.42
- mean corpuscular hemoglobin · score 0.42
- reticulocyte count · score 0.39
- reticulocyte measurement · score 0.36
- Immature Reticulocyte Fraction Measurement · score 0.33
- erythrocyte count · score 0.31
- Red cell distribution width · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75069-F1 | alphafold | PREDICTED | 60.15 | — |
Amino-acid sequence (709 residues)
MKRCRSDELQ QQQGEEDGAG LEDAASHLPG ADLRPGETTG ANSAGGPTSD AGAAAAPNPG PRSKPPDLKK IQQLSEGSMF GHGLKHLFHS RRRSREREHQ TSQDSQQHQQ QQGMSDHDSP DEKERSPEMH RVSYAMSLHD LPARPTAFNR VLQQIRSRPS IKRGASLHSS SGGGSSGSSS RRTKSSSLEP QRGSPHLLRK APQDSSLAAI LHQHQCRPRS SSTTDTALLL ADGSNVYLLA EEAEGIGDKV DKGDLVALSL PAGHGDTDGP ISLDVPDGAP DPQRTKAAID HLHQKILKIT EQIKIEQEAR DDNVAEYLKL ANNADKQQVS RIKQVFEKKN QKSAQTIAQL HKKLEHYRRR LKEIEQNGPS RQPKDVLRDM QQGLKDVGAN VRAGISGFGG GVVEGVKGSL SGLSQATHTA VVSKPREFAS LIRNKFGSAD NIAHLKDPLE DGPPEEAARA LSGSATLVSS PKYGSDDECS SASASSAGAG SNSGAGPGGA LGSPKSNALY GAPGNLDALL EELREIKEGQ SHLEDSMEDL KTQLQRDYTY MTQCLQEERY RYERLEEQLN DLTELHQNEM TNLKQELASM EEKVAYQSYE RARDIQEAVE SCLTRVTKLE LQQQQQQVVQ LEGVENANAR ALLGKFINVI LALMAVLLVF VSTIANFITP LMKTRLRITS TTLLVLVLFL LWKHWDSLTY LLEHVLLPS
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