About Low-density lipoprotein receptor-related protein 3
Low-density lipoprotein receptor-related protein 3 (LRP3) is a protein
from Homo sapiens identified by UniProt accession
O75074, 770 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | Low-density lipoprotein receptor-related protein 3 |
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| UniProt accession | O75074 |
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| Gene | LRP3 |
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| Organism | Homo sapiens |
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| Length | 770 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (44)
Diseases linked to this target (Open Targets).
- platelet count · score 0.07
- microphthalmia with limb anomalies · score 0.07
- mean corpuscular volume · score 0.07
- basophil count · score 0.07
- erythrocyte count · score 0.07
- mean corpuscular hemoglobin · score 0.07
- mean corpuscular hemoglobin concentration · score 0.07
- basophil percentage of leukocytes · score 0.07
- hematocrit · score 0.06
- red blood cell density measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75074-F1 | alphafold | PREDICTED | 67.43 | — |
Amino-acid sequence (770 residues)
MEKRAAAGLE GAPGARAQLA VVCLVNIFLT GRLSSAVPAL AACSGKLEQH TERRGVIYSP AWPLNYPPGT NCSWYIQGDR GDMITISFRN FDVEESHQCS LDWLLLGPAA PPRQEAFRLC GSAIPPAFIS ARDHVWIFFH SDASSSGQAQ GFRLSYIRGK LGQASCQADE FRCDNGKCLP GPWQCNTVDE CGDGSDEGNC SAPASEPPGS LCPGGTFPCS GARSTRCLPV ERRCDGLQDC GDGSDEAGCP DLACGRRLGS FYGSFASPDL FGAARGPSDL HCTWLVDTQD SRRVLLQLEL RLGYDDYVQV YEGLGERGDR LLQTLSYRSN HRPVSLEAAQ GRLTVAYHAR ARSAGHGFNA TYQVKGYCLP WEQPCGSSSD SDGGSLGDQG CFSEPQRCDG WWHCASGRDE QGCPACPPDQ YPCEGGSGLC YTPADRCNNQ KSCPDGADEK NCFSCQPGTF HCGTNLCIFE TWRCDGQEDC QDGSDEHGCL AAVPRKVITA ALIGSLVCGL LLVIALGCAF KLYSLRTQEY RAFETQMTRL EAEFVRREAP PSYGQLIAQG LIPPVEDFPV YSASQASVLQ NLRTAMRRQM RRHASRRGPS RRRLGRLWNR LFHRPRAPRG QIPLLTAARP SQTVLGDGFL QPAPGAAPDP PAPLMDTGST RAAGDRPPSA PGRAPEVGPS GPPLPSGLRD PECRPVDKDR KVCREPLVDG PAPADAPREP CSAQDPHPQV STASSTLGPH SPEPLGVCRN PPPPCSPMLE ASDDEALLVC
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