About WD repeat-containing protein 1
WD repeat-containing protein 1 (WDR1) is a protein
from Homo sapiens identified by UniProt accession
O75083, 606 residues long.
MolForge cross-references it against 0 known binders and
351 disease associations.
Target properties
| Protein name | WD repeat-containing protein 1 |
|---|
| UniProt accession | O75083 |
|---|
| Gene | WDR1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 606 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (351)
Diseases linked to this target (Open Targets).
- periodic fever, immunodeficiency, and thrombocytopenia syndrome · score 0.65
- urate measurement · score 0.61
- neurodegenerative disease · score 0.53
- creatinine measurement · score 0.44
- glomerular filtration rate · score 0.44
- intellectual developmental disorder 61 · score 0.42
- cortical surface area measurement · score 0.37
- serum metabolite measurement · score 0.33
- uric acid measurement · score 0.31
- atrial fibrillation · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75083-F1 | alphafold | PREDICTED | 96.50 | — |
Amino-acid sequence (606 residues)
MPYEIKKVFA SLPQVERGVS KIIGGDPKGN NFLYTNGKCV ILRNIDNPAL ADIYTEHAHQ VVVAKYAPSG FYIASGDVSG KLRIWDTTQK EHLLKYEYQP FAGKIKDIAW TEDSKRIAVV GEGREKFGAV FLWDSGSSVG EITGHNKVIN SVDIKQSRPY RLATGSDDNC AAFFEGPPFK FKFTIGDHSR FVNCVRFSPD GNRFATASAD GQIYIYDGKT GEKVCALGGS KAHDGGIYAI SWSPDSTHLL SASGDKTSKI WDVSVNSVVS TFPMGSTVLD QQLGCLWQKD HLLSVSLSGY INYLDRNNPS KPLHVIKGHS KSIQCLTVHK NGGKSYIYSG SHDGHINYWD SETGENDSFA GKGHTNQVSR MTVDESGQLI SCSMDDTVRY TSLMLRDYSG QGVVKLDVQP KCVAVGPGGY AVVVCIGQIV LLKDQRKCFS IDNPGYEPEV VAVHPGGDTV AIGGVDGNVR LYSILGTTLK DEGKLLEAKG PVTDVAYSHD GAFLAVCDAS KVVTVFSVAD GYSENNVFYG HHAKIVCLAW SPDNEHFASG GMDMMVYVWT LSDPETRVKI QDAHRLHHVS SLAWLDEHTL VTTSHDASVK EWTITY
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