Calcium-responsive transactivator (SS18L1)

About Calcium-responsive transactivator

Calcium-responsive transactivator (SS18L1) is a protein from Homo sapiens identified by UniProt accession O75177, 396 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.

Target properties

Protein name	Calcium-responsive transactivator
UniProt accession	O75177
Gene	SS18L1
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (113)

Diseases linked to this target (Open Targets).

amyotrophic lateral sclerosis · score 0.40
Amyotrophic lateral sclerosis · score 0.37
neurodegenerative disease · score 0.25
melanoma · score 0.19
hepatocellular carcinoma · score 0.19
B-cell acute lymphoblastic leukemia · score 0.18
gastric carcinoma · score 0.18
clear cell renal carcinoma · score 0.18
breast carcinoma · score 0.18
acute myeloid leukemia · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75177-F1	alphafold	PREDICTED	51.05	—

Amino-acid sequence (396 residues)

MSVAFASARP RGKGEVTQQT IQKMLDENHH LIQCILEYQS KGKTAECTQY QQILHRNLVY LATIADSNQN MQSLLPAPPT QNMNLGPGAL TQSGSSQGLH SQGSLSDAIS TGLPPSSLLQ GQIGNGPSHV SMQQTAPNTL PTTSMSISGP GYSHAGPASQ GVPMQGQGTI GNYVSRTNIN MQSNPVSMMQ QQAATSHYSS AQGGSQHYQG QSSIAMMGQG SQGSSMMGQR PMAPYRPSQQ GSSQQYLGQE EYYGEQYSHS QGAAEPMGQQ YYPDGHGDYA YQQSSYTEQS YDRSFEESTQ HYYEGGNSQY SQQQAGYQQG AAQQQTYSQQ QYPSQQSYPG QQQGYGSAQG APSQYPGYQQ GQGQQYGSYR APQTAPSAQQ QRPYGYEQGQ YGNYQQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards