About Transmembrane protein 127
Transmembrane protein 127 (TMEM127) is a protein
from Homo sapiens identified by UniProt accession
O75204, 238 residues long.
MolForge cross-references it against 0 known binders and
302 disease associations.
Target properties
| Protein name | Transmembrane protein 127 |
|---|
| UniProt accession | O75204 |
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| Gene | TMEM127 |
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| Organism | Homo sapiens |
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| Length | 238 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (302)
Diseases linked to this target (Open Targets).
- adrenal gland pheochromocytoma · score 0.81
- hereditary pheochromocytoma-paraganglioma · score 0.66
- hereditary neoplastic syndrome · score 0.57
- Inherited cancer-predisposing syndrome · score 0.57
- neuroendocrine carcinoma · score 0.37
- paragangliomas 1 · score 0.37
- Cowden syndrome 3 · score 0.37
- endocrine neoplasm · score 0.37
- carcinoid tumor · score 0.37
- melanoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75204-F1 | alphafold | PREDICTED | 77.62 | — |
Amino-acid sequence (238 residues)
MYAPGGAGLP GGRRRRSPGG SALPKQPERS LASALPGALS ITALCTALAE PAWLHIHGGT CSRQELGVSD VLGYVHPDLL KDFCMNPQTV LLLRVIAAFC FLGILCSLSA FLLDVFGPKH PALKITRRYA FAHILTVLQC ATVIGFSYWA SELILAQQQQ HKKYHGSQVY VTFAVSFYLV AGAGGASILA TAANLLRHYP TEEEEQALEL LSEMEENEPY PAEYEVINQF QPPPAYTP
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