About Leucine-rich repeat neuronal protein 2
Leucine-rich repeat neuronal protein 2 (LRRN2) is a protein
from Homo sapiens identified by UniProt accession
O75325, 713 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Leucine-rich repeat neuronal protein 2 |
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| UniProt accession | O75325 |
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| Gene | LRRN2 |
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| Organism | Homo sapiens |
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| Length | 713 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (46)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.45
- diet measurement · score 0.41
- mathematical ability · score 0.39
- hair color · score 0.31
- cutaneous melanoma · score 0.31
- antisocial behaviour measurement · score 0.30
- attention deficit hyperactivity disorder · score 0.30
- substance abuse · score 0.30
- intelligence · score 0.30
- Abnormal urine sodium concentration · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75325-F1 | alphafold | PREDICTED | 81.92 | — |
Amino-acid sequence (713 residues)
MRLLVAPLLL AWVAGATAAV PVVPWHVPCP PQCACQIRPW YTPRSSYREA TTVDCNDLFL TAVPPALPAG TQTLLLQSNS IVRVDQSELG YLANLTELDL SQNSFSDARD CDFHALPQLL SLHLEENQLT RLEDHSFAGL ASLQELYLNH NQLYRIAPRA FSGLSNLLRL HLNSNLLRAI DSRWFEMLPN LEILMIGGNK VDAILDMNFR PLANLRSLVL AGMNLREISD YALEGLQSLE SLSFYDNQLA RVPRRALEQV PGLKFLDLNK NPLQRVGPGD FANMLHLKEL GLNNMEELVS IDKFALVNLP ELTKLDITNN PRLSFIHPRA FHHLPQMETL MLNNNALSAL HQQTVESLPN LQEVGLHGNP IRCDCVIRWA NATGTRVRFI EPQSTLCAEP PDLQRLPVRE VPFREMTDHC LPLISPRSFP PSLQVASGES MVLHCRALAE PEPEIYWVTP AGLRLTPAHA GRRYRVYPEG TLELRRVTAE EAGLYTCVAQ NLVGADTKTV SVVVGRALLQ PGRDEGQGLE LRVQETHPYH ILLSWVTPPN TVSTNLTWSS ASSLRGQGAT ALARLPRGTH SYNITRLLQA TEYWACLQVA FADAHTQLAC VWARTKEATS CHRALGDRPG LIAILALAVL LLAAGLAAHL GTGQPRKGVG GRRPLPPAWA FWGWSAPSVR VVSAPLVLPW NPGRKLPRSS EGETLLPPLS QNS
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