Vesicle-associated membrane protein 4 (VAMP4)

About Vesicle-associated membrane protein 4

Vesicle-associated membrane protein 4 (VAMP4) is a protein from Homo sapiens identified by UniProt accession O75379, 141 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

Target properties

Protein name	Vesicle-associated membrane protein 4
UniProt accession	O75379
Gene	VAMP4
Organism	Homo sapiens
Length	141 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (50)

Diseases linked to this target (Open Targets).

Parkinson disease · score 0.17
open-angle glaucoma · score 0.13
blood protein measurement · score 0.13
platelet component distribution width · score 0.13
glaucoma · score 0.11
Juvenile glaucoma · score 0.10
mean platelet volume · score 0.08
platelet count · score 0.06
intelligence · score 0.05
Matthew-Wood syndrome · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75379-F1	alphafold	PREDICTED	81.28	—

Amino-acid sequence (141 residues)

MPPKFKRHLN DDDVTGSVKS ERRNLLEDDS DEEEDFFLRG PSGPRFGPRN DKIKHVQNQV DEVIDVMQEN ITKVIERGER LDELQDKSES LSDNATAFSN RSKQLRRQMW WRGCKIKAIM ALVAAILLLV IIILIVMKYR T

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards