Transcription initiation protein SPT3 homolog (SUPT3H)

About Transcription initiation protein SPT3 homolog

Transcription initiation protein SPT3 homolog (SUPT3H) is a protein from Homo sapiens identified by UniProt accession O75486, 317 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

Target properties

Protein name	Transcription initiation protein SPT3 homolog
UniProt accession	O75486
Gene	SUPT3H
Organism	Homo sapiens
Length	317 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (92)

Diseases linked to this target (Open Targets).

cleidocranial dysplasia 1 · score 0.38
metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome · score 0.33
Metaphyseal dysplasia - maxillary hypoplasia - brachydacty · score 0.33
body height · score 0.33
heel bone mineral density · score 0.31
bone quantitative ultrasound measurement · score 0.31
appendicular lean mass · score 0.29
lean body mass · score 0.27
bone density · score 0.27
nose morphology measurement · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75486-F1	alphafold	PREDICTED	80.38	—

Amino-acid sequence (317 residues)

MNNTAASPMS TATSSSGRST GKSISFATEL QSMMYSLGDA RRPLHETAVL VEDVVHTQLI NLLQQAAEVS QLRGARVITP EDLLFLMRKD KKKLRRLLKY MFIRDYKSKI VKGIDEDDLL EDKLSGSNNA NKRQKIAQDF LNSIDQTGEL LAMFEDDEID EVKQERMERA ERQTRIMDSA QYAEFCESRQ LSFSKKASKF RDWLDCSSME IKPNVVAMEI LAYLAYETVA QLVDLALLVR QDMVTKAGDP FSHAISATFI QYHNSAESTA ACGVEAHSDA IQPCHIREAI RRYSHRIGPL SPFTNAYRRN GMAFLAC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards