Serine/arginine-rich splicing factor 10 (SRSF10)

About Serine/arginine-rich splicing factor 10

Serine/arginine-rich splicing factor 10 (SRSF10) is a protein from Homo sapiens identified by UniProt accession O75494, 262 residues long. MolForge cross-references it against 0 known binders and 104 disease associations.

Target properties

Protein name	Serine/arginine-rich splicing factor 10
UniProt accession	O75494
Gene	SRSF10
Organism	Homo sapiens
Length	262 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (104)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
Red cell distribution width · score 0.24
chronotype measurement · score 0.12
hepatocellular carcinoma · score 0.10
acute myeloid leukemia · score 0.08
calf circumference measurement · score 0.07
neoplasm · score 0.05
appendicular lean mass · score 0.05
left ventricular noncompaction · score 0.05
hypertrophic cardiomyopathy · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75494-F1	alphafold	PREDICTED	61.00	—

Amino-acid sequence (262 residues)

MSRYLRPPNT SLFVRNVADD TRSEDLRREF GRYGPIVDVY VPLDFYTRRP RGFAYVQFED VRDAEDALHN LDRKWICGRQ IEIQFAQGDR KTPNQMKAKE GRNVYSSSRY DDYDRYRRSR SRSYERRRSR SRSFDYNYRR SYSPRNSRPT GRPRRSRSHS DNDRFKHRNR SFSRSKSNSR SRSKSQPKKE MKAKSRSRSA SHTKTRGTSK TDSKTHYKSG SRYEKESRKK EPPRSKSQSR SQSRSRSKSR SRSWTSPKSS GH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards