Heat shock factor-binding protein 1 (HSBP1)

About Heat shock factor-binding protein 1

Heat shock factor-binding protein 1 (HSBP1) is a protein from Homo sapiens identified by UniProt accession O75506, 76 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Heat shock factor-binding protein 1
UniProt accession	O75506
Gene	HSBP1
Organism	Homo sapiens
Length	76 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
systolic blood pressure · score 0.15
PHF-tau measurement · score 0.15
atopic eczema · score 0.14
diet measurement · score 0.08
mathematical ability · score 0.08
self reported educational attainment · score 0.07
cognitive function measurement · score 0.06
attention deficit hyperactivity disorder · score 0.05
antisocial behaviour measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75506-F1	alphafold	PREDICTED	87.20	—

Amino-acid sequence (76 residues)

MAETDPKTVQ DLTSVVQTLL QQMQDKFQTM SDQIIGRIDD MSSRIDDLEK NIADLMTQAG VEELESENKI PATQKS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards