About Tumor necrosis factor receptor superfamily member 21
Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) is a protein
from Homo sapiens identified by UniProt accession
O75509, 655 residues long.
MolForge cross-references it against 0 known binders and
332 disease associations.
Target properties
| Protein name | Tumor necrosis factor receptor superfamily member 21 |
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| UniProt accession | O75509 |
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| Gene | TNFRSF21 |
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| Organism | Homo sapiens |
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| Length | 655 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (332)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.44
- platelet count · score 0.42
- PHF-tau measurement · score 0.29
- breast adenocarcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.10
- neoplasm · score 0.09
- axial length measurement · score 0.08
- severe combined immunodeficiency due to CARD11 deficiency · score 0.07
- Hodgkins lymphoma · score 0.07
- classic Hodgkin lymphoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75509-F1 | alphafold | PREDICTED | 67.98 | — |
Amino-acid sequence (655 residues)
MGTSPSSSTA LASCSRIARR ATATMIAGSL LLLGFLSTTT AQPEQKASNL IGTYRHVDRA TGQVLTCDKC PAGTYVSEHC TNTSLRVCSS CPVGTFTRHE NGIEKCHDCS QPCPWPMIEK LPCAALTDRE CTCPPGMFQS NATCAPHTVC PVGWGVRKKG TETEDVRCKQ CARGTFSDVP SSVMKCKAYT DCLSQNLVVI KPGTKETDNV CGTLPSFSSS TSPSPGTAIF PRPEHMETHE VPSSTYVPKG MNSTESNSSA SVRPKVLSSI QEGTVPDNTS SARGKEDVNK TLPNLQVVNH QQGPHHRHIL KLLPSMEATG GEKSSTPIKG PKRGHPRQNL HKHFDINEHL PWMIVLFLLL VLVVIVVCSI RKSSRTLKKG PRQDPSAIVE KAGLKKSMTP TQNREKWIYY CNGHGIDILK LVAAQVGSQW KDIYQFLCNA SEREVAAFSN GYTADHERAY AALQHWTIRG PEASLAQLIS ALRQHRRNDV VEKIRGLMED TTQLETDKLA LPMSPSPLSP SPIPSPNAKL ENSALLTVEP SPQDKNKGFF VDESEPLLRC DSTSSGSSAL SRNGSFITKE KKDTVLRQVR LDPCDLQPIF DDMLHFLNPE ELRVIEEIPQ AEDKLDRLFE IIGVKSQEAS QTLLDSVYSH LPDLL
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