Enoyl-CoA delta isomerase 2 (ECI2)

About Enoyl-CoA delta isomerase 2

Enoyl-CoA delta isomerase 2 (ECI2) is a protein from Homo sapiens identified by UniProt accession O75521, 394 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.

Target properties

Protein name	Enoyl-CoA delta isomerase 2
UniProt accession	O75521
Gene	ECI2
Organism	Homo sapiens
Length	394 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (72)

Diseases linked to this target (Open Targets).

blood metabolite measurement · score 0.29
generalized anxiety disorder · score 0.25
balding measurement · score 0.20
gut microbiome measurement · score 0.18
depressive symptom measurement · score 0.16
neuroticism measurement · score 0.07
isolated asymptomatic elevation of creatine phosphokinase · score 0.07
attention deficit hyperactivity disorder · score 0.05
substance abuse · score 0.05
antisocial behaviour measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75521-F1	alphafold	PREDICTED	87.41	—

Amino-acid sequence (394 residues)

MAMAYLAWRL ARRSCPSSLQ VTSFPVVQLH MNRTAMRASQ KDFENSMNQV KLLKKDPGNE VKLKLYALYK QATEGPCNMP KPGVFDLINK AKWDAWNALG SLPKEAARQN YVDLVSSLSP SLESSSQVEP GTDRKSTGFE TLVVTSEDGI TKIMFNRPKK KNAINTEMYH EIMRALKAAS KDDSIITVLT GNGDYYSSGN DLTNFTDIPP GGVEEKAKNN AVLLREFVGC FIDFPKPLIA VVNGPAVGIS VTLLGLFDAV YASDRATFHT PFSHLGQSPE GCSSYTFPKI MSPAKATEML IFGKKLTAGE ACAQGLVTEV FPDSTFQKEV WTRLKAFAKL PPNALRISKE VIRKREREKL HAVNAEECNV LQGRWLSDEC TNAVVNFLSR KSKL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards