Syntaxin-11 (STX11)

About Syntaxin-11

Syntaxin-11 (STX11) is a protein from Homo sapiens identified by UniProt accession O75558, 287 residues long. MolForge cross-references it against 0 known binders and 168 disease associations.

Target properties

Protein name	Syntaxin-11
UniProt accession	O75558
Gene	STX11
Organism	Homo sapiens
Length	287 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (168)

Diseases linked to this target (Open Targets).

Familial hemophagocytic lymphohistiocytosis · score 0.78
viral load · score 0.32
genetic disorder · score 0.19
autoinflammatory syndrome · score 0.18
inflammatory bowel disease · score 0.15
mature T-cell and NK-cell non-Hodgkin lymphoma · score 0.08
eosinophil percentage of leukocytes · score 0.06
X-linked lymphoproliferative disease · score 0.05
Immunodeficiency by defective expression of HLA class 2 · score 0.05
neutrophil count · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75558-F1	alphafold	PREDICTED	78.89	—

Amino-acid sequence (287 residues)

MKDRLAELLD LSKQYDQQFP DGDDEFDSPH EDIVFETDHI LESLYRDIRD IQDENQLLVA DVKRLGKQNA RFLTSMRRLS SIKRDTNSIA KAIKARGEVI HCKLRAMKEL SEAAEAQHGP HSAVARISRA QYNALTLTFQ RAMHDYNQAE MKQRDNCKIR IQRQLEIMGK EVSGDQIEDM FEQGKWDVFS ENLLADVKGA RAALNEIESR HRELLRLESR IRDVHELFLQ MAVLVEKQAD TLNVIELNVQ KTVDYTGQAK AQVRKAVQYE EKNPCRTLCC FCCPCLK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards